The series on the scientific achievements by our INVITE fellows continues. Here Bruno Dos Santos Lima presents its research on Alzheimer’s disease.<\/p>\n\n\n\n
During the INVITE PhD program, I have dedicated my time dissecting the role of neutrophils in the pathogenesis of Alzheimer\u2019s disease. In more detail, my PhD thesis focused on the role of the gut microbiome dysbiosis in the modulation and activation of peripheral neutrophils in Alzheimer\u2019s disease. <\/p>\n\n\n\n
Furthermore, I have also investigated how activated neutrophils may promote cognitive deficits at the central level by addressing neutrophil functions and dysregulation in the brain of Alzheimer\u2019s disease mouse models. <\/p>\n\n\n\n
Alzheimer\u2019s disease constitutes nowadays one of the most pressing matters worldwide. With the rapid ageing of the population, increased prevalence and incidence of the disease, Alzheimer\u2019s disease constitutes a huge social and economic problem, and no cure or effective therapy has been found to counteract this issue. The research project I am involved in aims to contribute to a better understanding of the pathogenic mechanism underlying Alzheimer\u2019s disease cognitive deficits, providing targets to develop effective therapies for Alzheimer\u2019s disease patients.<\/p>\n\n\n\n